International Top Pharmaceutical Awards

  Viral infectious diseases have caused millions of deaths worldwide. Antiviral agents are critical for controlling these infections; however, an open-access database dedicated specifically to antiviral agents remains unavailable. Here, we present AntiviralDB  an expert-curated resource that compiles both approved and experimental antiviral agents with laboratory-confirmed   in vitro   activity against a broad spectrum of human viruses. These include the human immunodeficiency virus, coronaviruses, hepatitis viruses, influenza virus, respiratory syncytial virus, herpes simplex virus, varicella-zoster virus, human cytomegalovirus, human papillomavirus, dengue virus, Zika virus, Ebola virus, mpox virus, norovirus, chikungunya virus, and 16 other common or life-threatening pathogens. Each antiviral agent in the database is annotated with key information, including its molecular target,   in vitro   antiviral activity (IC 50 , EC 50 , and CC 50   across sp...

  Scientists identify a key enzyme enabling cancer cells to rapidly rewire DNA, accelerating mutations, adaptation, and treatment resistance across tumors. Visit Our Website : toppharmaceutical.org Nomination link : https://toppharmaceutical.org/award-nomination/?ecategory=Awards&rcategory=Awardee Contact us : contact@toppharmaceutical.org #Cancer #Enzyme #DNA #Mutation #Genomics #Oncology #Biology #Research #Science #Medicine #Tumor

  Three years ago, Portnoy cofounded a startup, Laguna Biotherapeutics, that worked with scientists in his University of California, Berkeley lab to eliminate the bacteria's ability to cause disease while retaining its ability to rev up production of a type of immune system cell associated with increased survival in cancer patients. These so-called  gamma delta T cells  are general-purpose killers of cancer cells or any cell infected by a pathogen—bacteria, virus, or fungus. Laguna Bio will soon ask the FDA for clearance to evaluate the therapy in children with leukemia who have received unmatched bone marrow transplants. Stanford University Medical Center doctors hope that the engineered Listeria will boost gamma delta T cells in pediatric patients and help them stave off graft-versus-host disease, fight potentially deadly infections that take advantage of a transplant patient's compromised immune system, and prevent the cancer from returning. Portnoy and his colleagues ...

  Alembic Pharmaceuticals Ltd  has received final approval from the US Food & Drug Administration (USFDA) for its Abbreviated New Drug Application (ANDA) Carbidopa, Levodopa and Entacapone Tablets, 12.5 mg/50 mg/200 mg, 18.75 mg/75 mg/200 mg, 25 mg/100 mg/200 mg, 31.25 mg/125 mg/200 mg, 37.5 mg/150 mg/200 mg, and 50 mg/200 mg/200 mg. Carbidopa, levodopa and entacapone tablets are indicated for the treatment of Parkinson’s disease.  IPCA Laboratories  informed the exchanges that manufacturing facility at Tarapur (Maharashtra) has now received Establishment Inspection Report classifying the manufacturing facility as “Voluntary Action Indicated (VAI) and that this facility is considered to be in a minimally acceptable state of compliance with regard to current good manufacturing practice (CGMP) from the US FDA. Earlier, it  Zydus Lifescience , a leading, discovery-based, global pharmaceutical company has announced that the USFDA has granted Orphan Drug Des...

  It's easy to feel powerless against cancer, but a new study has identified several ways that we can reduce the odds of it occurring. According to new analysis from the World Health Organization (WHO), more than a third of all cancer cases globally are preventable. Lung, stomach, and cervical cancers make up nearly half of those cases. This means that millions of deadly cancers every year could be prevented through medical intervention, behavior changes, reducing occupational risks, or tackling environmental pollutants. "Addressing these preventable causes represents one of the most powerful opportunities to reduce the global cancer burden," says Isabelle Soerjomataram, medical epidemiologist at WHO and senior author of the analysis. Visit Our Website : toppharmaceutical.org  Nomination link : https://toppharmaceutical.org/award-nomination/?ecategory=Awards&rcategory=Awardee                  ...

  In the realm of organ transplantation, the integration of pharmacogenomics into clinical practice has emerged as a transformative approach that holds the potential to significantly enhance patient outcomes. The recent literature, particularly a review by researchers K.D. Belfield, E.A. Cohen, and G. Girone, sheds light on the profound implications of pharmacogenomics in transplantation. This exciting field explores how an individual’s genetic makeup can influence their response to medications, thereby revolutionizing personalized medicine in organ transplant recipients. At the heart of pharmacogenomics is the interaction between genetics and drug metabolism. Each patient possesses a unique genetic profile that impacts how their body processes medications. In the context of transplantation, this means that the standard immunosuppressive therapies often prescribed may not be equally effective for every individual. By understanding these genetic variances, clinicians can tailor medi...