International Top Pharmaceutical Awards

  Alembic Pharmaceuticals Ltd  has received final approval from the US Food & Drug Administration (USFDA) for its Abbreviated New Drug Application (ANDA) Carbidopa, Levodopa and Entacapone Tablets, 12.5 mg/50 mg/200 mg, 18.75 mg/75 mg/200 mg, 25 mg/100 mg/200 mg, 31.25 mg/125 mg/200 mg, 37.5 mg/150 mg/200 mg, and 50 mg/200 mg/200 mg. Carbidopa, levodopa and entacapone tablets are indicated for the treatment of Parkinson’s disease.  IPCA Laboratories  informed the exchanges that manufacturing facility at Tarapur (Maharashtra) has now received Establishment Inspection Report classifying the manufacturing facility as “Voluntary Action Indicated (VAI) and that this facility is considered to be in a minimally acceptable state of compliance with regard to current good manufacturing practice (CGMP) from the US FDA. Earlier, it  Zydus Lifescience , a leading, discovery-based, global pharmaceutical company has announced that the USFDA has granted Orphan Drug Des...

  It's easy to feel powerless against cancer, but a new study has identified several ways that we can reduce the odds of it occurring. According to new analysis from the World Health Organization (WHO), more than a third of all cancer cases globally are preventable. Lung, stomach, and cervical cancers make up nearly half of those cases. This means that millions of deadly cancers every year could be prevented through medical intervention, behavior changes, reducing occupational risks, or tackling environmental pollutants. "Addressing these preventable causes represents one of the most powerful opportunities to reduce the global cancer burden," says Isabelle Soerjomataram, medical epidemiologist at WHO and senior author of the analysis. Visit Our Website : toppharmaceutical.org  Nomination link : https://toppharmaceutical.org/award-nomination/?ecategory=Awards&rcategory=Awardee                  ...

  In the realm of organ transplantation, the integration of pharmacogenomics into clinical practice has emerged as a transformative approach that holds the potential to significantly enhance patient outcomes. The recent literature, particularly a review by researchers K.D. Belfield, E.A. Cohen, and G. Girone, sheds light on the profound implications of pharmacogenomics in transplantation. This exciting field explores how an individual’s genetic makeup can influence their response to medications, thereby revolutionizing personalized medicine in organ transplant recipients. At the heart of pharmacogenomics is the interaction between genetics and drug metabolism. Each patient possesses a unique genetic profile that impacts how their body processes medications. In the context of transplantation, this means that the standard immunosuppressive therapies often prescribed may not be equally effective for every individual. By understanding these genetic variances, clinicians can tailor medi...

  Every time we think we’re close to fully understanding the human body, something fresh and unexpected shows up. Recently, a team of researchers stumbled upon strange entities, or obelisks, living inside of human bodies that had escaped notice until now. These new visitors appear smaller than the viruses most people learn about in basic biology classes. Rather than behaving like familiar microbes, they introduce themselves as something different. Their discovery came about when researchers began analyzing massive genetic libraries, searching for patterns that did not match any known organisms. Visit Our Website : toppharmaceutical.org  Nomination link : https://toppharmaceutical.org/award-nomination/?ecategory=Awards&rcategory=Awardee                                                              ...

  Two decades after a breast cancer vaccine trial, every participant is still alive—an astonishing result for metastatic disease. Scientists found their immune systems retained long-lasting memory cells primed to recognize cancer. By enhancing a key immune signal called CD27, researchers dramatically improved tumor elimination in lab studies. The findings suggest cancer vaccines may have been missing a crucial ingredient all along. A decades-old cancer vaccine left patients’ immune systems fighting strong—and scientists may have finally figured out why. Credit: Shutterstock More than two decades ago, a small group of women with advanced breast cancer took part in a clinical trial that tested an experimental vaccine. All these years later, every one of them is still alive. Researchers say survival over such a long period is extremely uncommon for people with metastatic breast cancer, which is why the case drew renewed scientific attention. Researchers at Duke Health took a closer lo...

  Researchers unveil a first-in-class inhibitor that shuts down a key epigenetic switch driving lung cancer growth. A research team by Professor Xiang David Li from the Department of Chemistry at The University of Hong Kong (HKU), in collaboration with researchers from the Shenzhen Bay Laboratory and Tsinghua University, has made a breakthrough in epigenetic drug discovery. The team has successfully developed a first-in-class chemical inhibitor that precisely and selectively targets the ATAC complex, a critical cellular “switch operator” that activates tumour-promoting genes, opening a novel therapeutic avenue for non-small cell lung cancer (NSCLC). The findings were recently published in the top-tier journal  Nature Chemical Biology , and multiple international patent applications have been filed. Histone Modifications as Genetic Switches in Our Cells Inside human cells, DNA is wrapped around protein structures called histones to form chromatin. Chemical modifi...